Journal: International Journal of Molecular Sciences
Article Title: High Expression of miR-34a Associated with Less Aggressive Cancer Biology but Not with Survival in Breast Cancer
doi: 10.3390/ijms21093045
Figure Lengend Snippet: High MiR-34a breast cancer associate with lower gene sets variation analysis (GSVA) scores of the gene sets related to cell cycle or cell proliferation in whole METABRIC cohort and each subtype. Upper row: E2F_Targets, middle row: G2M_Checkpoint, lower row: Mitotic_Spindle Hallmark gene sets. GSVA, Gene Set Variant Analysis.
Article Snippet: GSVA scoring of Hallmark gene sets, such as E2F_TARGETS, G2M_CHECKPOINT, MITOTIC_SPINDLE, APOPTOSIS, and EPITHELIAL_MESENCHYMAL_ TRANSITION was utilized in this study ( , C, , and ) Broad Institute ( http://software.broadinstitute.org/gsea/index.jsp ) provides the publicly available software to perform Gene set enrichment analysis (GSEA).
Techniques: Variant Assay